There should be an elliptical Update button in the bottom right, just below that thin horizontal line. If it's not there, I suggest checking the Java console for jQuery errors and also the server logs for any errors. You can also inspect the page to see if the button is there and just hidden for some reason. This feels like a plugin or theme conflict.
Looks like the bottom part of the page is cut off.
There was no errors, and no plugin conflict either which was also my first consideration. What it was in the end was that the front end CSS I had used to add a bottom margin was also being applied to the backend and obstructing the bottom.
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Can you send a screenshot?